Poor Artemis is wrapped in a straitjacket and locked in a room. What she doesn't know is Alexis is enduring the same fate right next door! Eventually, the gals figure out someone else besides the crazy nurse Dorothy is around by knocking on the wall between them. Dorothy finds that her two prisoners are communicating so she tries to keep them apart longer by binding them even more, but Alexis manages to get free and goes to the aid of Artemis. Once that's done, all they have to do is force Dorothy into a straitjacket of her own and then escape from The Institute.